Rfc 4497

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor (VEGF) favor edema formation, while others such as erythropoietin (Epo) can mitigate it. Both factors are controlled by hypoxia inducible transcription factors (HIF) and the activity of prolyl hydroxylase domain p...

Quebec Health Minister blames former CEO for MUHC deficit, resulting cuts.

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the α subunit of the hypoxia-inducible factor (HIF) in vitro and in cultured cells, but nothing is known about its roles in mammalian erythropoiesis. We studied such roles here by administering a HIF-P4H inhibitor, FG-4497, to P4h-tm(-/-) mice. This caused larger increases in serum Epo concentration and ...

Proposing New Algorithm for Modeling of Regenerative Fuel Cell (RFC) System

Regenerative Fuel Cell (RFC) systems are used for the enhancement of sustainable energy aspect in conventional fuel cells. In this study, a photovoltaic-electrolyzer-fuel cell integrated cycle has been presented. The proposed system has been designed as a novel approach for alleviating the restrictions  on energy streams in the RFC systems. Modeling of the system has been performed from the mas...

Effect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (RFC-1)

Arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. The hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (NTDs) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. In this study, sodium arsenate was administered via intraperitoneal route at a r...